TB 2016 Posters - Sunday 17 July 2016

Understanding TB Infectiousness and Transmission

P02 Global transcriptome analysis reveals up-regulation of host cytokine genes, and cytokine and chemokine receptor binding in BALB/c mice by Mycobacterium tuberculosis curli pili (MTP).
P66 Comparison of indoor contact time in Zambia and South Africa suggests targeting of interventions to reduce Mycobacterium tuberculosis transmission should be informed by local data.
P67 A5300/I2003: feasibility of identifying, recruiting and characterizing adult MDR TB index cases and their adult and child household contacts on four continents.
P68 Extensively drug-resistant M. tuberculosis strains of the F15/LAM4/KZN genotype exhibit enhanced proinflammatory cytokine induction in THP-1 macrophages.

New Advances in Clinical Research including Pediatric TB

P35 IMPAACT P1113/aeras C-015-404: Phase I/II study of H4:IC31 in BCG-primed infants
P36 Serial plasma cytokine levels in childhood tuberculosis: potential biomarkers for predicting therapeutic outcome.
P37 Initial management of MDR-TB in HIV co-infected patients in Eastern Europe: results from the TB:HIV study.
P38 Updated preliminary results of treatment of multidrug-resistant tuberculosis (MDR-TB) with a 9-month regimen in francophone Africa.

New Tools, R&D Drugs, Diagnostics and Vaccines

P01 Use of QuantiFERON ®-TB Gold assay in clinical trials: effect of immediate incubation and temperature variations during transportation on assay outcomes.
P70 Resolution of discordant rifampicin genotypic and phenotypic drug susceptibility testing in TB/HIV coinfected  patients.
P39 Prevalence of bedaquiline resistance-conferring mutations in drug resistant tuberculosis patients in South Africa.
P41 Development of an in-house single step loop mediated isothermal amplification assay for the detection of Mycobacterium tuberculosis complex in sputum samples from moroccan patients.
P42 Affordability of comprehensive MDR-TB treatment with novel regimens, at current prices versus estimated competitive generic prices.
P43 Laboratory detection of rifampicin low level resistance in Mycobacterium tuberculosis.
P44 Evaluation of the fluorotype MTB assay for detection of Mycobacterium tuberculosis complex DNA in fineneedle aspiration biopsy (FNAB) specimens.
P45 DNA extracted from used Xpert MTB/RIF cartridges can be used for second-line drug susceptibility testing.
P46 Identification of biomarkers predictive of early stage tuberculosis infection.
P47 Effect of sputum quality and volume on the yield of bacteriologically confirmed TB by Xpert and smear microscopy among people living with HIV in Botswana.
P48 Early morning urine collection to improve urinary LAM lateral flow assay sensitivity in hospitalised patients with HIV-TB co-infection.
P49 Evaluation of Anyplex II™ MTB/MDR-TB for rapid detection of multidrug resistant tuberculosis (MDR-TB) on clinical sediments.
P50 Comparison between Bedaquiline minimum inhibitory concentrations using the agar proportion method and the Sensititre broth microdilution method.
P51 Decreased sensitivity and increased indeterminate rates of GenoType MTBDRplus (v2.0) are associated with use of inappropriate PCR ramp rate: implications for routine diagnostic laboratories.

Community Engagement and Innovations

P07 Lessons learned with the implementation of household TB screening, diagnosis and initiation of TB treatment in South Africa.
P08 Building the capacity of local language media to report on TB.
P09 Impact of directly-observed treatment support offered by local NGO in Mahikeng Sub-district, Ngaka Modiri Molema District, North West Province, 2013 – 2014.
P10 Improving the quality of data to improve TB treatment outcomes in Sub-district A, Nelson Mandela Bay Health District, South Africa.
P11 Tackling TB in early childhood development centres in Ethekwini Metro, KwaZulu Natal, South Africa.
P12 Introduction of TB screening services in 17 correctional setting through a non-governmental organization.
P13 Active case finding revealing the hidden face of tuberculosis within 80 slum areas in Oyo State of Nigeria.
P14 Advancing towards TB elimination - significant contribution by rural health care providers (RHCPs) to national TB program using mobile technology in Tribal District of India.
P15 A pilot study to evaluate the experiences of TB patients when accessing TB services in five health facilities in Kisumu – Kenya.
P16 Treatment adherence among TB patients in the private sector - combination of technology and human touch.
P77 Tuberculosis eCurriculum series: a web-based self-paced education program.
P78 Eh!woza
P80 Beyond the lab and behind the lens: an exploration of a community engagement initiative and its reflection of the lived experience of TB in Khayelitsha.
P83 Disease surveillance through mobile phones: Geotagging the ‘smart-phone’ way.

Translational Research

P64 Lung tissue resident T cell immune responses to Mycobacterium tuberculosis infection in humans